David Duchovny Ira Kane

Julianne Moore Allison Reed

Orlando Jones Harry Block

Seann William Scott Wayne Grey

Ted Levine General Russell Woodman

Ethan Suplee Deke Donald

Michael Bower Danny Donal

Pat Kilbane Officer Sam Johnson

Ty Burrell Colonel Flemming

Dan Aykroyd Governor Lewis

Katharine Towne Nadine

Gregory Itzin Barry Cartwright

Ashley Clark Lt. Cryer

Michelle Wolff Carla

Sarah Silverman Denise

Richard Moll Fire Training Inspector

Michael McGrady Fireman

Steven Gilborn Judge Guilder

Wayne Duvall Dr. Paulson

Michael Chapman Sheriff Long

Kyle Gass Officer Drake

Lucas Dudley Sgt. Toms

Steven Pierce Sgt. Larson

Wendy Braun Nurse Tate

Jennifer Savidge Claire

Jerry Trainor Tommy

Stephanie Hodge Jill Mason

Kristen Meadows Patty

Winifred Freedman Debbi

Miriam Flynn Grace

Mary Pat Gleason Customer

Tony Mirzoian Husband

Morgan Nagler Dressing Room Girl

Andrew Bowen Road Worker

Steve Kehela Reporter

Lee Garlington Reporter

Josh Ackerman Studen

Kenn Michael Studen

John Cho Student

Tressa Pope Student

Adrienne Smith Student

Chris Wylde Student

Marty Belafsky Military Police

Lee Weaver Military Police

Tom Davis Governor's Aide

Gary Kent Governor's Aide

Timothy R. Layton Guard Gate Soldier

Angelo Vacco Officer Thompson

Jim Brockhohn Volleyball Spectator (uncredited)

Erin Carufel Tina (uncredited)

Diondre Cheatam Campus Security Officer (uncredited)

Johnny Drocco Lab Tech / Man Catching Falling Lady (uncredited)

Nasi Glekas Construction Foreman (uncredited)

Paul G. Gray Reporter (uncredited)

Earl Maddox Lab Tech (uncredited)

Leslie McCasky Waitress (uncredited)

John P. Napoleon Army soldier (uncredited)

Tom Woodruff Jr. Lead Primate Creature (uncredited)