Paul Matthews is a lonely biochemist with a crush on his unavailable co-worker, Diane Farrow. His friends take him to a gypsy on 34th and Vine named Madame Ruth.
After reading his palm and seeing absolutely no romance in his life, Ruth gives him a small bottle of very diluted Love Potion No. 8. As a scientist, Paul has doubts, and ends up throwing it in the trash when he gets home. Around this time, Paul's friends buy him the services of Marisa.