Picking up immediately after he hits the ground at the end of Crank, Chev Chelios is kidnapped by a gang of Chinese medics. On an operating table, they attempt to harvest his organs. But after they remove his heart and replace it with an electronic temporary one, Chev wakes up and kills the medics. He then has to chase after the gang who has stolen his heart. At the same time, he must keep shocking himself with regular jolts of electricity to keep himself alive.