During the Chipmunks' benefit concert in Paris, France, David Seville suffers a severe injury and is rushed to the hospital. Although he survives, he must stay for a few days to recuperate, so he leaves his cousin Toby in charge of the Chipmunks until he returns. Prior to the event, Dave had made arrangements for Alvin, Simon, and Theodore to attend school. Little does he know, on their very first day, the Chipmunks feel like "Chipmunks Out of Water" on account of all the human students around.